Endocrine Abstracts

Background: The severity of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM) population compared with that in normal glucose tolerance (NGT) individuals has not yet been assessed by a quantitative method. We investigated the prevalence and the severity of NAFLD in a T2DM population using controlled attenuation parameter (CAP).Methods: Subjects who underwent testing for biomarkers related to T2DMand CAP using Fibroscan during a...

Objective: The association between albuminuria and peripheral artery disease (PAD) could be confounded by renal function. Albuminuria reflects generalized disruption of endothelial cell function. This study was conducted to examine the association of PAD with low glomerular filtration rate (GFR) and albuminuria in diabetic patients.Methods: A total of 254 diabetic patients were included. We examined the age, sex, duration of diabetes, GFR, urinary albumi...

Heme oxygenase-1 (HO-1) catalyzes the conversion of heme to carbon monoxide, free iron, and biliverdin, which is then changed into bilirubin. These substances have been recently demonstrated to have antiatherogenic and antioxidative properties. The GT-repeat polymorphism is reported to be an independent risk factor for restenosis after coronary stenting and T (−413). A polymorphism increased the activity of HO-1 promoter, leading to reduce the incidence of ischemic heart...

Objective: Cilostazol, a selective inhibitor of phosphodiesterase 3, which has been widely used in patients with atherosclerotic diseases, is known to have additional beneficial effects on dyslipidemia. ATP-binding cassette transporter A1 (ABCA1) plays a critical role in the regulation of intracellular cholesterol levels in hepatocytes. We aimed to investigate the effect of Cilostazol on hepatic steatosis and its underlying mechanism related to ABCA1.Met...

Introduction: The mortality rate from cardiovascular disease (CVD) among young adults has declined less than that in the older population, raising concerns about the increasing prevalence of obesity-related conditions including hypercholesterolemia in the younger population. We investigated the age-standardized mean levels of serum cholesterols and the prevalence, awareness, treatment and control rates of hyper-LDL-cholesterolemia based on age.Methods: N...